N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

Base Information

Chemical Name:N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine
CAS No.:1563175-39-2
Molecular Formula:C₃₁H₄₃N₅OS
Molecular Weight:533.781
Hs Code.:

Synonyms:N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

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Chemical Property of N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

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Technology Process of N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

There total 8 articles about N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1563175-33-6
4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butanal

: 104617-86-9
2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

: 1563175-39-2
N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm401883v

Reference yield:

: 1225962-32-2
1-(3′-methoxy-biphenyl-4-yl)piperazine

: 1563175-39-2
N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.33 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; potassium carbonate; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; acetonitrile; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/jm401883v

Reference yield:

: 1563175-23-4
1-(4-((t-butyldimethylsilyl)oxy)butyl)-4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazine

: 1563175-39-2
N6-(4-(4-(3′-methoxy-[1,1′-biphenyl]-4-yl)piperazin-1-yl)butyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.33 h / 20 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jm401883v