C₃₈H₃₄N₂O₈

Base Information

• Chemical Name: C₃₈H₃₄N₂O₈
• CAS No.: 1449768-53-9
• Molecular Formula: C₃₈H₃₄N₂O₈
• Molecular Weight: 646.697
• Mol file: 1449768-53-9.mol

Synonyms:C₃₈H₃₄N₂O₈

Chemical Property of C₃₈H₃₄N₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₃₄N₂O₈

There total 3 articles about C₃₈H₃₄N₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-(benzofuran-2-yl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (1449768-52-8) + 4,4'-dimethoxytrityl chloride (40615-36-9) → C38H34N2O8 (1449768-53-9)

Guidance literature:

With pyridine; dmap; at 20 ℃;

DOI:10.1002/cbic.201200408

Reference yield:

5-Iodo-2'-deoxyuridine (54-42-2,162239-35-2) → C38H34N2O8 (1449768-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 90 °C

2: pyridine; dmap / 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1: |Stille Cross Coupling;

DOI:10.1002/cbic.201200408

Reference yield:

2-(tri-n-butylstannyl)benzofuran → C38H34N2O8 (1449768-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 90 °C

2: pyridine; dmap / 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1: |Stille Cross Coupling;

DOI:10.1002/cbic.201200408

upstream raw materials:

5-Iodo-2'-deoxyuridine

5-(benzofuran-2-yl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

4,4'-dimethoxytrityl chloride

Downstream raw materials:

C₄₇H₅₁N₄O₉P

Refernces