(S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 869081-64-1
• Molecular Formula: C₄₁H₅₆N₄O₇
• Molecular Weight: 716.918
• Mol file: 869081-64-1.mol

Synonyms:(S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester

There total 6 articles about (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid (222530-34-9,218772-92-0,222530-33-8) → (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester (869081-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HATU; DIEA / CH₂Cl₂

2: piperidine / CH₂Cl₂

3: HBTU; DIEA / CH₂Cl₂

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;

DOI:10.1021/ol0518885

Reference yield:

Boc-D-γ-Ach-L-MeN-Ala-OFm (869081-61-8) → (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester (869081-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / CH₂Cl₂

2: HBTU; DIEA / CH₂Cl₂

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/ol0518885

Reference yield:

2-methylamino-propionic acid 9H-fluoren-9-ylmethyl ester → (S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid 9H-fluoren-9-ylmethyl ester (869081-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HATU; DIEA / CH₂Cl₂

2: TFA / CH₂Cl₂

3: HBTU; DIEA / CH₂Cl₂

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;

DOI:10.1021/ol0518885

upstream raw materials:

Boc-D-γ-Ach-L-^MeN-Ala-OH

D-γ-Ach-L-^MeN-Ala-OFm

(1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid

L-Boc-^MeN-Ala-OFm

Downstream raw materials:

(S)-2-[((1S,3R)-3-{(S)-2-[((1S,3R)-3-Amino-cyclohexanecarbonyl)-methyl-amino]-propionylamino}-cyclohexanecarbonyl)-methyl-amino]-propionic acid