7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

Base Information

Chemical Name:7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride
CAS No.:1610521-68-0
Molecular Formula:C₂₄H₃₀N₂O₄S*ClH
Molecular Weight:479.04
Hs Code.:

Synonyms:7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

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Chemical Property of 7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

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Technology Process of 7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

There total 6 articles about 7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.4%

: 221298-00-6
(3-methylpiperidin-3-yl)methanol

: 1610520-45-0
7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610521-68-0
7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: (3-methylpiperidin-3-yl)methanol; 7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 17h; Inert atmosphere;

With hydrogenchloride; water;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610521-68-0
7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 17 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; 1,2-dichloro-ethane;

Reference yield:

: 1610520-27-8
4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610521-68-0
7-(3,4-dimethoxyphenyl)-2-((3-(hydroxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 17 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane;