1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate
CAS No.:1620320-18-4
Molecular Formula:C₁₈H₂₄N₂O₇
Molecular Weight:380.398
Hs Code.:

Synonyms:1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

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Chemical Property of 1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

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Technology Process of 1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

There total 3 articles about 1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1620320-18-4
1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With silver(l) oxide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Molecular sieve;
DOI:10.1039/c4cc03660c

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1620320-18-4
1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: silver(l) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere; Molecular sieve

With dmap; triethylamine; silver(l) oxide; In dichloromethane;
DOI:10.1039/c4cc03660c

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1620320-18-4
1-(tert-butyl) 2-methyl (2S,4R)-4-((4-nitrobenzyl)oxy)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: silver(l) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere; Molecular sieve

With dmap; triethylamine; silver(l) oxide; In dichloromethane;
DOI:10.1039/c4cc03660c