N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

Base Information

Chemical Name:N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide
CAS No.:1345842-44-5
Molecular Formula:C₂₁H₂₀N₄O₄S
Molecular Weight:424.48
Hs Code.:

Synonyms:N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

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Chemical Property of N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

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Technology Process of N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

There total 4 articles about N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 477515-23-4
C₁₉H₁₈N₄O₃

: 68-11-1
mercaptoacetic acid

: 1345842-44-5
N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

Guidance literature:: With zinc(II) chloride; In N,N-dimethyl-formamide; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.09.003

Reference yield:

: 85-44-9
phthalic anhydride

: 1345842-44-5
N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 8 h / Heating

2: hydrazine hydrate; dicyclohexyl-carbodiimide / dichloromethane / 0 - 3 °C

3: acetic acid / ethanol / Reflux

4: zinc(II) chloride / N,N-dimethyl-formamide / Microwave irradiation

With hydrazine hydrate; acetic acid; dicyclohexyl-carbodiimide; zinc(II) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.003

Reference yield:

: 4702-13-0
N-phthaloylglycine

: 1345842-44-5
N-[2-(4-dimethylaminophenyl)-4-oxothiazolidin-3-yl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate; dicyclohexyl-carbodiimide / dichloromethane / 0 - 3 °C

2: acetic acid / ethanol / Reflux

3: zinc(II) chloride / N,N-dimethyl-formamide / Microwave irradiation

With hydrazine hydrate; acetic acid; dicyclohexyl-carbodiimide; zinc(II) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.003