2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

Base Information

Chemical Name:2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester
CAS No.:1027397-14-3
Molecular Formula:C₂₇H₃₆ClNO₁₁
Molecular Weight:586.036
Hs Code.:

Synonyms:2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

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Chemical Property of 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

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Technology Process of 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

There total 11 articles about 2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913623-05-9
5-(2-chloro-3,5-dihydroxy-6-((4-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)butoxy)carbonyl)phenyl)pentanoic acid

: 1027397-14-3
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h;
DOI:10.1021/jo061054f

Reference yield:

: 913622-69-2
4-(2-methoxy-3,6-bis(methoxymethoxy)phenyl)butan-1-ol

: 1027397-14-3
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NH₄NO₃; (CF₃CO)2O / tetrahydrofuran / 1 h / 20 °C

1.2: 85 percent / LiOH / tetrahydrofuran; methanol; H₂O / 0.17 h

2.1: 84 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

3.1: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

4.1: 279 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

5.1: H₂ / Pd/C / ethanol / 3 h

With ammonium nitrate; 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; tert-butyl alcohol; 2.1: Mitsunobu esterification;
DOI:10.1021/jo061054f

Reference yield:

: 913622-70-5
4-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)butan-1-ol

: 1027397-14-3
2-(4-carboxy-butyl)-3-chloro-4,6-dihydroxy-benzoic acid 4-(3-amino-6-methoxy-2,5-bis-methoxymethoxy-phenyl)-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

2: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

3: 279 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

4: H₂ / Pd/C / ethanol / 3 h

With 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; tert-butyl alcohol; 1: Mitsunobu esterification;
DOI:10.1021/jo061054f