tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate
CAS No.:1126475-23-7
Molecular Formula:C₂₆H₂₈FN₃O₄
Molecular Weight:465.524
Hs Code.:

Synonyms:tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

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Technology Process of tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

There total 3 articles about tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126475-20-4
1-(3-carboxy-4-fluorobenzyl)-4-oxo-1,4-dihydroquinolinium chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1126475-23-7
tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

Guidance literature:: 1-(3-carboxy-4-fluorobenzyl)-4-oxo-1,4-dihydroquinolinium chloride; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 0.333333h;

1-t-Butoxycarbonylpiperazine; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1126475-23-7
tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 - 20 °C

2.2: pH 1

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.33 h

3.2: 1 h

With lithium hydroxide; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 709-45-5
2-fluoro-5-bromomethyl benzoic acid methyl ester

: 1126475-23-7
tert-butyl 4-{2-fluoro-5-[(4-oxoquinolin-1(4H)-yl)methyl]benzoyl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 - 20 °C

2.2: pH 1

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.33 h

3.2: 1 h

With lithium hydroxide; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;