(7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

Base Information

Chemical Name:(7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien
CAS No.:1263286-72-1
Molecular Formula:C₃₉H₆₆O₄SSi₂
Molecular Weight:687.188
Hs Code.:

Synonyms:(7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

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Chemical Property of (7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

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Technology Process of (7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

There total 9 articles about (7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1263286-71-0
(7aR)-7a-methyl-1-((S)-1'-(phenylsulfonyl)propane-2'-yl)hexahydro-1H-inden-4(2H)-on

: 139356-39-1
(1R,3R)-1,3-bis((tert-butyldimethyl)silanyloxy)-5-[2-(diphenylphosphinoyl)-ethylidene]cyclohexane

: 1263286-72-1
(7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

Guidance literature:: (1R,3R)-1,3-bis((tert-butyldimethyl)silanyloxy)-5-[2-(diphenylphosphinoyl)-ethylidene]cyclohexane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃;

(7aR)-7a-methyl-1-((S)-1'-(phenylsulfonyl)propane-2'-yl)hexahydro-1H-inden-4(2H)-on; In tetrahydrofuran; hexane; at -60 - -40 ℃; for 2h;

Reference yield:

: 145372-32-3
des-A,B-22-iodo-23,24-dinorcholan-8-one

: 1263286-72-1
(7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 1.5 h / 80 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0 °C

2.2: 2 h / -60 - -40 °C

With n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 1263286-72-1
(7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; triphenylphosphine; iodine / dichloromethane / 20 h

2.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0 °C

4.2: 2 h / -60 - -40 °C

With n-butyllithium; iodine; triethylamine; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;