Propikacin

Base Information

Chemical Name:Propikacin
CAS No.:66887-96-5
Molecular Formula:C₂₁H₄₃N₅O₁₂
Molecular Weight:557.599
Hs Code.:
UNII:9X6F5H479X
DSSTox Substance ID:DTXSID501024406
Nikkaji Number:J19.081K
Wikidata:Q27273343
NCI Thesaurus Code:C75063
ChEMBL ID:CHEMBL4594229

Synonyms:1-N-(1,3-dihydroxy-2-propyl)kanamycin B;UK 31,214;UK 31214;UK-31214;UK31214

Suppliers and Price of Propikacin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Propikacin

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:910.965°C at 760 mmHg
PKA:13.07±0.70(Predicted)
Flash Point:504.733°C
PSA：314.87000
Density:1.588g/cm³
LogP:-5.14880
XLogP3:-8
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:10
Exact Mass:557.29082182
Heavy Atom Count:38
Complexity:728

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C(C(C1NC(CO)CO)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)N)N
Isomeric SMILES:C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(CO)CO)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)N)N
Uses Antibacterial.

Technology Process of Propikacin

There total 8 articles about Propikacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₆H₇₅N₅O₂₄

: 66887-96-5
1-N-(1,3-dihydroxy-2-propyl)kanamycin B

Guidance literature:: Multi-step reaction with 5 steps

1: H₂, CH₃COOH / Pd-C (5 percent) / tetrahydrofuran; H₂O / 50 °C / 2585.7 Torr

2: aq. NH₃ / H₂O / 24 h / Ambient temperature

3: tetrahydrofuran; H₂O

4: sodium cyanoborohydride / methanol; H₂O

5: aq. caustic solution / H₂O

With ammonium hydroxide; caustic solution; hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)71171-3

Reference yield:

: 65269-36-5
N,N'-bis-benzyloxycarbonyl-O⁴-(3-benzyloxycarbonylamino-α-D-3-deoxy-glucopyranosyl)-O⁶-(2,6-bis-benzyloxycarbonylamino-α-D-2,6-dideoxy-glucopyranosyl)-1L-2-deoxy-streptamine

: 66887-96-5
1-N-(1,3-dihydroxy-2-propyl)kanamycin B

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 24 h / Ambient temperature

2: H₂, CH₃COOH / Pd-C (5 percent) / tetrahydrofuran; H₂O / 50 °C / 2585.7 Torr

3: aq. NH₃ / H₂O / 24 h / Ambient temperature

4: tetrahydrofuran; H₂O

5: sodium cyanoborohydride / methanol; H₂O

6: aq. caustic solution / H₂O

With ammonium hydroxide; caustic solution; hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; water;
DOI:10.1016/S0040-4039(00)71171-3

Reference yield:

: 70551-00-7
2',3'',6'-tri-N-acetylkanamycin B

: 66887-96-5
1-N-(1,3-dihydroxy-2-propyl)kanamycin B

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; H₂O

2: sodium cyanoborohydride / methanol; H₂O

3: aq. caustic solution / H₂O

With caustic solution; sodium cyanoborohydride; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)71171-3