(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Base Information

Chemical Name:(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone
CAS No.:329744-64-1
Molecular Formula:C₁₄H₁₆F₂O₃
Molecular Weight:270.276
Hs Code.:

Synonyms:(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

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Technology Process of (2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

There total 2 articles about (2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 38573-88-5
1-bromo-2,3-difluorobenzene

: 135270-08-5
4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine

: 329744-64-1
(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Guidance literature:: 1-bromo-2,3-difluorobenzene; With magnesium; methyl iodide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1.5h;

4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine; In tetrahydrofuran; diethyl ether; at -30 ℃; Further stages.;
DOI:10.1016/j.jfluchem.2005.12.008

Reference yield:

: 329744-64-1
(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Guidance literature:

Reference yield:

: 329744-64-1
(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

: 18171-11-4
chloromethylisopropoxydimethylsilane

: 329744-66-3
(2S,3R)-2-(2,3-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-butan-2-ol

Guidance literature:: chloromethylisopropoxydimethylsilane; With magnesium; In diethyl ether;

(2R)-2',3'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.5h; Further stages.;
DOI:10.1016/j.jfluchem.2005.12.008