Boc-γ²hhVal-γ²hhAla-γ²hhLeu-OBn

Base Information

• Chemical Name: Boc-γ²hhVal-γ²hhAla-γ²hhLeu-OBn
• CAS No.: 423184-13-8
• Molecular Formula: C₃₂H₅₃N₃O₆
• Molecular Weight: 575.789
• Mol file: 423184-13-8.mol

Synonyms:Boc-γ²hhVal-γ²hhAla-γ²hhLeu-OBn

Chemical Property of Boc-γ²hhVal-γ²hhAla-γ²hhLeu-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-γ²hhVal-γ²hhAla-γ²hhLeu-OBn

There total 2 articles about Boc-γ²hhVal-γ²hhAla-γ²hhLeu-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-{2-[(tert-butoxycarbonyl)amino]ethyl}-3-methylbutanoic acid (259857-55-1) + (R)-2-[2-((R)-4-Amino-2-methyl-butyrylamino)-ethyl]-4-methyl-pentanoic acid benzyl ester; compound with trifluoro-acetic acid → Boc-γ2hhVal-γ2hhAla-γ2hhLeu-OBn (423184-13-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃;

DOI:10.1002/1521-3765(20020201)8:3<573::AID-CHEM573>3.0.CO;2-H

Reference yield:

(S)-2-{2-[(tert-butoxycarbonyl)amino]ethyl}-3-methylbutanoic acid (259857-55-1) + 2-[2-(4-amino-2-methyl-butyrylamino)-ethyl]-4-methyl-pentanoic acid benzyl ester → Boc-γ2hhVal-γ2hhAla-γ2hhLeu-OBn (423184-13-8)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1021/jm070148u

Reference yield:

Boc-γ2hhVal-γ2hhAla-γ2hhLeu-OBn (423184-13-8) → 2-{2-[4-(2-{2-[2-(2-{4-[2-(2-tert-butoxycarbonylamino-ethyl)-3-methyl-butyrylamino]-2-methyl-butyrylamino}-ethyl)-4-methyl-pentanoylamino]-ethyl}-3-methyl-butyrylamino)-2-methyl-butyrylamino]-ethyl}-4-methyl-pentanoic acid benzyl ester (356783-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd/C / methanol / 12 h / 20 °C / 750.08 Torr

2: 401 mg / 4-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxy-1H-benzotriazole / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; dichloromethane;

DOI:10.1002/1521-3765(20020201)8:3<573::AID-CHEM573>3.0.CO;2-H

upstream raw materials:

(S)-2-{2-[(tert-butoxycarbonyl)amino]ethyl}-3-methylbutanoic acid

Downstream raw materials:

2-{2-[4-(2-{2-[2-(2-{4-[2-(2-tert-butoxycarbonylamino-ethyl)-3-methyl-butyrylamino]-2-methyl-butyrylamino}-ethyl)-4-methyl-pentanoylamino]-ethyl}-3-methyl-butyrylamino)-2-methyl-butyrylamino]-ethyl}-4-methyl-pentanoic acid benzyl ester