C₇₅H₉₅O₁₈P₃

Base Information

• Chemical Name: C₇₅H₉₅O₁₈P₃
• CAS No.: 207981-84-8
• Molecular Formula: C₇₅H₉₅O₁₈P₃
• Molecular Weight: 1377.49
• Mol file: 207981-84-8.mol

Synonyms:C₇₅H₉₅O₁₈P₃

Chemical Property of C₇₅H₉₅O₁₈P₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₅H₉₅O₁₈P₃

There total 15 articles about C₇₅H₉₅O₁₈P₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,12-dibromododecane (3344-70-5) → C75H95O18P3 (207981-84-8)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.) di-n-butyltin oxide; 2.) CsF / 1.) MeOH; 2.) DMF, rt.

2: 90 percent / DMAP / pyridine

3: 86 percent / ceric ammonium nitrate / acetonitrile; H₂O

4: 80 percent / K₂CO₃ / methanol

5: 100 percent / p-TsOH

6: 83 percent / K₂CO₃ / dimethylformamide / Ambient temperature

7: 82 percent / p-TsOH / CH₂Cl₂

8: 86 percent / imidazole / dimethylformamide / Ambient temperature

9: 100 percent / DMAP / pyridine; CH₂Cl₂ / Ambient temperature

10: 96 percent / HCl / H₂O; ethanol / 1 h / Ambient temperature

11: 85 percent / NPCl / pyridine / 0.25 h / Ambient temperature

12: 67 percent / PPTS / ethane-1,2-diol; CH₂Cl₂

13: 1.) 1H-tetrazole; 2.) mCPBA / 1.) rt., 2 h, CH₂Cl₂; 2.) from -40 degC to rt.

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; dmap; ammonium cerium(IV) nitrate; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; In pyridine; methanol; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)00418-3

Reference yield:

(R)-1-(12-Bromo-dodecyloxy)-3-(4-methoxy-phenoxy)-propan-2-ol (207981-71-3) → C75H95O18P3 (207981-84-8)

Guidance literature:

Multi-step reaction with 12 steps

1: 90 percent / DMAP / pyridine

2: 86 percent / ceric ammonium nitrate / acetonitrile; H₂O

3: 80 percent / K₂CO₃ / methanol

4: 100 percent / p-TsOH

5: 83 percent / K₂CO₃ / dimethylformamide / Ambient temperature

6: 82 percent / p-TsOH / CH₂Cl₂

7: 86 percent / imidazole / dimethylformamide / Ambient temperature

8: 100 percent / DMAP / pyridine; CH₂Cl₂ / Ambient temperature

9: 96 percent / HCl / H₂O; ethanol / 1 h / Ambient temperature

10: 85 percent / NPCl / pyridine / 0.25 h / Ambient temperature

11: 67 percent / PPTS / ethane-1,2-diol; CH₂Cl₂

12: 1.) 1H-tetrazole; 2.) mCPBA / 1.) rt., 2 h, CH₂Cl₂; 2.) from -40 degC to rt.

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; dmap; ammonium cerium(IV) nitrate; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In pyridine; methanol; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)00418-3

Reference yield:

(3aS,4S,5S,5aR,8aS,8bS)-5-Benzyloxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-ol (139686-87-6) → C75H95O18P3 (207981-84-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) PCl₃, imidazole, Et₃N / 1.) -15 degC, 80 min

2: 85 percent / NPCl / pyridine / 0.25 h / Ambient temperature

3: 67 percent / PPTS / ethane-1,2-diol; CH₂Cl₂

4: 1.) 1H-tetrazole; 2.) mCPBA / 1.) rt., 2 h, CH₂Cl₂; 2.) from -40 degC to rt.

With 1H-imidazole; 1H-tetrazole; pyridinium p-toluenesulfonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; phosphorus trichloride; In pyridine; dichloromethane; ethylene glycol;

DOI:10.1016/S0040-4039(98)00418-3

upstream raw materials:

Dibenzyl N,N-diisopropylphosphoramidite

C₄₇H₆₉O₁₂P

1,12-dibromododecane

(3aS,4S,5S,5aR,8aS,8bS)-5-Benzyloxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-ol

Downstream raw materials:

Hexanoic acid (R)-2-{[(3aR,4S,5S,6R,7R,7aS)-5-benzyloxy-6,7-bis-(bis-benzyloxy-phosphoryloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-yloxy]-hydroxy-phosphoryloxy}-1-[12-(naphthalen-2-yloxy)-dodecyloxymethyl]-ethyl ester