methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Base Information

Chemical Name:methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate
CAS No.:361337-01-1
Molecular Formula:C₁₁H₁₀F₃NO₈S
Molecular Weight:373.264
Hs Code.:

Synonyms:methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

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Chemical Property of methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

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Technology Process of methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

There total 1 articles about methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 361337-00-0
methyl (6-hydroxy-2-methoxy-3-nitrophenyl)acetate

: 361337-01-1
methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030233b

Reference yield:

: 361337-01-1
methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

: 361336-71-2
N-(4-carbamimidoyl-benzyl)-2-(4-isopropylamino-3-methoxy-biphenyl-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: Pd(PPh₃)4; LiCl / dioxane / 85 °C

2: Fe; AcOH / 80 °C

3: NaHB(OAc)3 / CH₂Cl₂; tetrahydrofuran

4: NaOH / methanol / 65 °C

5: HOBt; NMM; polystyrene-bound carbodiimide / CH₂Cl₂; dimethylformamide

6: H₂ / Pd/C / methanol

With 4-methyl-morpholine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; polystyrene-bound carbodiimide; hydrogen; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1016/j.bmcl.2003.08.002

Reference yield:

: 361337-01-1
methyl (2-methoxy-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

: N-(4-carbamimidoyl-benzyl)-2-(3-methoxy-4-phenethylamino-biphenyl-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 74 percent / (Ph₃P)4Pd; LiCl / dioxane / 85 °C

2.1: Fe; glacial AcOH / 80 °C

3.1: 56 percent / NaHB(OAc)3; AcOH / tetrahydrofuran; CH₂Cl₂ / 20 °C

4.1: 100 percent / aq. NaOH / methanol / 65 °C

5.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

5.2: 0.52 g / N-methylmorpholine / CH₂Cl₂; dimethylformamide

6.1: 81 percent / H₂ / Pd/C / methanol / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; PS-carbodiimide; hydrogen; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Stille coupling;
DOI:10.1021/jm030233b