(9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:(9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate
CAS No.:1447589-03-8
Molecular Formula:C₃₅H₄₃N₃O₇
Molecular Weight:617.742
Hs Code.:

Synonyms:(9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Property of (9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

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Technology Process of (9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

There total 4 articles about (9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 68858-20-8
Fmoc-Val-OH

: 1447589-02-7
(2R,3R)-N-isobutyl-2,3-dimethoxy-3-(2-nitrophenyl)propan-1-amine

: 1447589-03-8
(9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 6h;
DOI:10.1002/ejoc.201300408

Reference yield:

: 1447589-01-6
(2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propan-1-amine

: 1447589-03-8
(9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 0.5 h

2: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

With sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300408

Reference yield:

: C₁₅H₂₂N₂O₄

: 1447589-03-8
(9H-fluoren-9-yl)methyl (S)-1-(((2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propyl)(isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

With sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300408