11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

Base Information

Chemical Name:11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid
CAS No.:123226-46-0
Molecular Formula:C₂₃H₂₁NO₅S₂
Molecular Weight:455.555
Hs Code.:

Synonyms:11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

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Chemical Property of 11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

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Technology Process of 11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

There total 5 articles about 11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123226-64-2
methyl 11-[2-[(phenylsulfonyl)amino]ethyl]thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

: 123226-46-0
11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; for 2.5h; Heating;
DOI:10.1021/jm00096a016

Reference yield:

: 79669-87-7
methyl 11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

: 123226-46-0
11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol

2: p-toluenesulfonic acid

3: 96 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

5: 10 N aq. NaOH / H₂O; methanol / 2.5 h / Heating

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jm00096a016

Reference yield:

: 79669-90-2
methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate

: 123226-46-0
11-[2-[(Phenylsulfonyl)amino]ethyl]thio-6, 11-dihydrodibenz-[b,e]oxepin-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid

2: 96 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

4: 10 N aq. NaOH / H₂O; methanol / 2.5 h / Heating

With sodium hydroxide; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jm00096a016