{5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

Base Information

Chemical Name:{5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine
CAS No.:1420998-32-8
Molecular Formula:C₂₁H₂₁N₅O₃
Molecular Weight:391.429
Hs Code.:

Synonyms:{5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

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Chemical Property of {5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

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Technology Process of {5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

There total 11 articles about {5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1420998-26-0
4-(2-chloro-oxazol-5-yl)-2-(2-methoxy-imidazol-1-yl)pyridine

: 1420998-31-7
N-(5-methoxymethyl-2-methyl-phenyl)acetamide

: 1420998-32-8
{5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

Guidance literature:: N-(5-methoxymethyl-2-methyl-phenyl)acetamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

4-(2-chloro-oxazol-5-yl)-2-(2-methoxy-imidazol-1-yl)pyridine; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 3h;

Reference yield:

: 84540-59-0
4-methyl-3-nitrobenzyl chloride

: 1420998-32-8
{5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 16 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 16 h / 20 °C

2.2: pH 6 - 7

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

4.2: 3 h / 0 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sodium hydride; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 4926-28-7
2-Bromo-4-picoline

: 1420998-32-8
{5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: tert.-butylnitrite; potassium tert-butylate / tetrahydrofuran / 3 h / -10 °C / Inert atmosphere

1.2: pH 6 - 7

2.1: hydrogenchloride; formaldehyd / water / 4 h / -10 °C

2.2: pH 6 - 7

3.1: potassium carbonate / methanol / 16 h / 20 °C

4.1: potassium carbonate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 96 h / 110 °C / Sealed tube

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

6.1: methanol; tetrahydrofuran / 16 h / 0 - 50 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

7.2: 16 h / -78 - 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

8.2: 3 h / 0 °C

With hydrogenchloride; copper(l) iodide; formaldehyd; tert.-butylnitrite; potassium tert-butylate; sodium hydride; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;