Technology Process of 1-(6-methyl-8-nitroquino-5-yl)-1'-(5-benzoylthien-2-yl)ferrocene
There total 1 articles about 1-(6-methyl-8-nitroquino-5-yl)-1'-(5-benzoylthien-2-yl)ferrocene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium chloride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
N,N-dimethyl-formamide;
the mixt. of ferrocene and bromide in dry DMF was heated on an oil bath to 120°C, the catalyst PdCl2(dppf) was added, then the mixt. was stirred at 120-130°C for 1.5 h and then cooled to room temp.; satd. NH4Cl soln. was added, then the mixt. was extd. with ether or CH2Cl2, washed with satd. KF soln. and water, organic phase was dried over MgSO4, concd. in vac., chromd. (silica gel);
DOI:10.1016/S0022-328X(00)00496-4
