Technology Process of Bzls-D-Phe(3-AMe-Cbz)-OH
There total 6 articles about Bzls-D-Phe(3-AMe-Cbz)-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
H-D-Phe(3-AMe-Cbz)-OH*TFA;
With
chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 1h;
Reflux;
benzenesulfonyl chloride;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
pH=8 - 9;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / 40 °C
2.1: 4-methyl-morpholine / acetonitrile / Cooling with ice
3.1: dichloromethane / 1 h
4.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Reflux
4.2: 0 - 20 °C / pH 8 - 9
With
4-methyl-morpholine; chloro-trimethyl-silane; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / 1,4-dioxane; water / 6 h / 0 - 20 °C / pH 8 - 9
2.1: hydrogen / palladium 10% on activated carbon / 40 °C
3.1: 4-methyl-morpholine / acetonitrile / Cooling with ice
4.1: dichloromethane / 1 h
5.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Reflux
5.2: 0 - 20 °C / pH 8 - 9
With
4-methyl-morpholine; chloro-trimethyl-silane; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; water; acetonitrile;
