2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester
CAS No.:849752-40-5
Molecular Formula:C₃₂H₃₃F₃N₂O₈S
Molecular Weight:662.684
Hs Code.:

2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

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Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

There total 3 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: C₁₀H₈ClF₃O₄S

: 170943-16-5
methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate

: 849752-40-5
2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2004.12.052

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 849752-40-5
2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / CH₂Cl₂ / 0 - 20 °C

2: 88 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

3: 69 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2004.12.052

Reference yield:

: 172846-56-9
methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

: 849752-40-5
2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

2: 69 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2004.12.052