Technology Process of (R)-2-(4-Methoxy-phenyl)-4-((S)-1-methyl-allyl)-[1,3]dioxane
There total 1 articles about (R)-2-(4-Methoxy-phenyl)-4-((S)-1-methyl-allyl)-[1,3]dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 75 percent / NaOH; H2O2 / tetrahydrofuran
2: 77 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 0.25 h
With
sodium hydroxide; dihydrogen peroxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol035797o
- Guidance literature:
-
With
oxygen; copper diacetate;
palladium dichloride;
In
N,N-dimethyl acetamide; water;
for 12h;
DOI:10.1021/ol070517g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 70 percent / oxygen; copper(II) acetate monohydrate / PdCl2 / N,N-dimethyl-acetamide; H2O / 12 h
2.1: ethyldiisopropylamine; dibutylboron triflate / CH2Cl2; diethyl ether / -78 - -50 °C
2.2: CH2Cl2; diethyl ether / 6 h / -78 - -50 °C
2.3: 72 percent / aq. H2O2 / various solvents / pH 7
3.1: diethyl(methoxy)borane; NaBH4 / tetrahydrofuran; methanol / -78 °C
3.2: 85 percent / methanol
4.1: 81 percent / ethyldiisopropylamine / CHCl3 / 12 h / 65 °C
With
sodium tetrahydroborate; di-n-butylboryl trifluoromethanesulfonate; diethyl methoxy borane; oxygen; copper diacetate; N-ethyl-N,N-diisopropylamine;
palladium dichloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; N,N-dimethyl acetamide; water;
1.1: Wacker reaction / 2.2: Evans aldol reaction;
DOI:10.1021/ol070517g
