tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate
• CAS No.: 1207438-49-0
• Molecular Formula: C₁₈H₂₂ClFN₂O₂
• Molecular Weight: 352.836

Synonyms:tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate

Chemical Property of tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-butyl 4-[(3-chloro-4-fluorophenyl)(cyano)methylidene]piperidine-1-carboxylate (1207438-42-3) → tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate (1207438-49-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmc.2013.05.025

Reference yield:

2-(3-chloro-4-fluorophenyl)acetonitrile (658-98-0) → tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate (1207438-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

With sodium tetrahydroborate; sodium methylate; In methanol;

DOI:10.1016/j.bmc.2013.05.025

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-[(RS)-(3-chloro-4-fluorophenyl)(cyano)methyl]piperidine-1-carboxylate (1207438-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

With sodium tetrahydroborate; sodium methylate; In methanol;

DOI:10.1016/j.bmc.2013.05.025

upstream raw materials:

tert-butyl 4-[(3-chloro-4-fluorophenyl)(cyano)methylidene]piperidine-1-carboxylate

2-(3-chloro-4-fluorophenyl)acetonitrile

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chloro-4-fluorophenyl)ethanoic acid

tert-butyl 4-[(1RS)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

tert-butyl 4-[(1RS)-1-(3-chloro-4-fluorophenyl)-2-methoxyethyl]piperidine-1-carboxylate

4-[(1RS)-1-(3-chloro-4-fluorophenyl)-2-methoxyethyl]piperidine monohydrochloride

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