[6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

Base Information

Chemical Name:[6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate
CAS No.:1383926-29-1
Molecular Formula:C₂₂H₂₀F₃NO₄S
Molecular Weight:451.466
Hs Code.:

Synonyms:[6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

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Chemical Property of [6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

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Technology Process of [6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

There total 5 articles about [6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383926-13-3
2,2-dimethyl-propionic acid 6,6-dioxo-7-(2-trifluoromethyl-phenyl)-5,6-dihydro-thiopyrano[4,3-b]pyridin-8-yl ester

: 107-04-0
1-Bromo-2-chloroethane

: 1383926-29-1
[6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

Guidance literature:: With 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); In tetrahydrofuran; at 20 ℃; for 21h;

Reference yield:

: 1383926-71-3
thioacetic acid S-(2-trifluoromethyl-benzyl) ester

: 1383926-29-1
[6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / methanol / 0.5 h / 20 °C

1.2: 2.5 h / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 11 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 3.5 h / 20 °C

4.1: pyridine / dichloromethane / 16 h / 0 - 20 °C

5.1: 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene) / tetrahydrofuran / 21 h / 20 °C

With pyridine; potassium tert-butylate; potassium carbonate; 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 116986-09-5
3-bromomethyl-pyridine-2-carboxylic acid methyl ester

: 1383926-29-1
[6',6'-dioxo-7'-[2-(trifluoromethyl)phenyl]spiro[cyclopropane-1,5'-thiopyrano[4,3-b]pyridine]-8'-yl] 2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / methanol / 0.5 h / 20 °C

1.2: 2.5 h / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 11 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 3.5 h / 20 °C

4.1: pyridine / dichloromethane / 16 h / 0 - 20 °C

5.1: 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene) / tetrahydrofuran / 21 h / 20 °C

With pyridine; potassium tert-butylate; potassium carbonate; 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;