ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate

Base Information

• Chemical Name: ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate
• CAS No.: 409113-03-7
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Mol file: 409113-03-7.mol

Synonyms:ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate

Chemical Property of ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate

There total 13 articles about ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl (E)-2-(p-methoxyphenylimino)acetate (115276-75-0,124156-21-4,120419-96-7) + pentan-3-one (96-22-0) → ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate (409113-03-7)

Guidance literature:

N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide; In dimethyl sulfoxide; at 20 ℃; for 20h; Product distribution / selectivity;

Reference yield: 83.0%

ethyl (E)-2-(p-methoxyphenylimino)acetate (115276-75-0,124156-21-4,120419-96-7) + pentan-3-one (96-22-0) → ethyl 2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate + ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate (409113-03-7)

Guidance literature:

(S)-2-(trifluoromethane-sulfonylamino-methyl)-pyrrolidine; In dimethyl sulfoxide; at 20 ℃; for 20h;

DOI:10.1016/j.tetlet.2004.08.032

Reference yield: 72.0%

ethyl N-(p-methoxyphenyl)iminoacetate (124156-21-4) + ethyl isopropyl ketone (565-69-5) → ethyl (2S,3S)-2-(4-methoxyphenylamino)-3-methyl-4-oxo-hexanoate (409113-03-7)

Guidance literature:

With L-proline; In dimethyl sulfoxide; at 20 ℃; for 2h;

upstream raw materials:

ethyl (E)-2-(p-methoxyphenylimino)acetate

pentan-3-one

ethyl (4-methoxyphenylimino)acetate

ethyl (2S,3R)-2-(p-methoxyphenylamino)-3-methyl-4-oxohexanoate

Downstream raw materials:

ethyl (2S,3R)-2-(p-methoxyphenylamino)-3-methyl-4-oxohexanoate