rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

Base Information

Chemical Name:rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester
CAS No.:956223-21-5
Molecular Formula:C₃₃H₃₇N₅O₄
Molecular Weight:567.688
Hs Code.:

Synonyms:rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

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Chemical Property of rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

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Technology Process of rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

There total 2 articles about rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 956223-22-6
4-(4-benzyl-piperazin-1-yl)-6-chloro-pyrimidin-2-ylamine

: 223126-69-0
3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester

: 956223-21-5
rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 1141923-52-5
3-[4-(2-Amino-6-chloro-pyrimidin-4-yloxy)-phenyl]-2-methyl-2-phenoxy-propionic acid ethyl ester

: 956223-21-5
rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmc.2009.05.082

Reference yield: 95.0%

: 956223-21-5
rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester

: 956223-04-4
3-{4-[2-amino-6-(4-benzylpiperazin-1-yl)pyrimidin-4-yloxy]phenyl}-2-methyl-2-phenoxypropionic acid

Guidance literature:: rac-3-{4-[2-amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester; With potassium hydroxide; water; In tetrahydrofuran; for 20h;

In water; pH=6;