Technology Process of 6-Benzenesulfonyl-9-methyl-1,3,4,4a,5,6,7,8-octahydro-2H-benzocycloheptene
There total 4 articles about 6-Benzenesulfonyl-9-methyl-1,3,4,4a,5,6,7,8-octahydro-2H-benzocycloheptene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Na-naphthalene; titanium tetrachloride;
In
tetrahydrofuran;
for 4h;
Heating;
DOI:10.1021/jo00022a042
- Guidance literature:
-
Multi-step reaction with 5 steps
1: TsOH*H2O, 3 Angstroem molecular sieves / benzene / 3 h / Heating
2: 1.) n-BuLi, 2.) HMPA / 1.) hexane, THF, -78 deg C, 20 min, 2.a) -30 deg C, 40 min, b) 0 deg C, 2 h
3: aq. HCl / tetrahydrofuran / 40 °C
4: 85 percent / PdCl2, CuCl, O2 / H2O; dimethylsulfoxide / 0.25 h / Heating
5: 39 percent / Na-naphthalene, TiCl4 / tetrahydrofuran / 4 h / Heating
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 3 A molecular sieve; Na-naphthalene; oxygen; titanium tetrachloride; toluene-4-sulfonic acid; copper(l) chloride; palladium dichloride;
In
tetrahydrofuran; water; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00022a042
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi, 2.) HMPA / 1.) hexane, THF, -78 deg C, 20 min, 2.a) -30 deg C, 40 min, b) 0 deg C, 2 h
2: aq. HCl / tetrahydrofuran / 40 °C
3: 85 percent / PdCl2, CuCl, O2 / H2O; dimethylsulfoxide / 0.25 h / Heating
4: 39 percent / Na-naphthalene, TiCl4 / tetrahydrofuran / 4 h / Heating
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; Na-naphthalene; oxygen; titanium tetrachloride; copper(l) chloride; palladium dichloride;
In
tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/jo00022a042
