Aminomorphine

Base Information

• Chemical Name: Aminomorphine
• CAS No.: 51006-03-2
• Molecular Formula: C₁₇H₂₀N₂O₃
• Molecular Weight: 300.357
• DSSTox Substance ID: DTXSID20965288
• Nikkaji Number: J66.309C
• Wikidata: Q82947478
• Mol file: 51006-03-2.mol

Synonyms:Aminomorphine;Morphine, amino-;BRN 0046575;51006-03-2;Morphinan-3,6-alpha-diol, 2-amino-7,8-didehydro-4,5-alpha-epoxy-17-methyl-;2-27-00-00472 (Beilstein Handbook Reference);2-amino morphine;SCHEMBL11684980;DTXSID20965288;LS-91719;2-Amino-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol;2-Amino-17-methyl-4,5alpha-epoxy-7,8-didehydromorphinan-3,6alpha-diol;Morphinan-3,6-diol, 2-amino-7,8-didehydro-4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)-

Chemical Property of Aminomorphine

Chemical Property:

• Vapor Pressure: 2.18E-11mmHg at 25°C
• Boiling Point: 514°C at 760 mmHg
• Flash Point: 264.6°C
• PSA: 78.95000
• Density: 1.49g/cm³
• LogP: 1.29940
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 300.14739250
• Heavy Atom Count: 22
• Complexity: 526

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=CC(=C(C(=C52)OC3C(C=C4)O)O)N
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=CC(=C(C(=C52)O[C@H]3[C@H](C=C4)O)O)N

Technology Process of Aminomorphine

There total 6 articles about Aminomorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-nitromorphine (49751-21-5) → 2-aminomorphine (51006-03-2)

Guidance literature:

With sodium hydroxide; formamidine; In ethanol; at 90 ℃; for 1h;

DOI:10.1016/j.tet.2008.08.069

Reference yield:

MORPHIN (57-27-2) → 2-aminomorphine (51006-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite / water

2: hydrogenchloride; tin / water

With hydrogenchloride; tin; sodium nitrite; In water;

DOI:10.1007/s00706-010-0380-7

Reference yield:

→ 2-Amino-morphin (51006-03-2)

Guidance literature:

With hydrogenchloride; tin;

upstream raw materials:

2-nitromorphine

MORPHIN