4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol

Base Information

• Chemical Name: 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol
• CAS No.: 120312-51-8
• Molecular Formula: C₂₇H₄₂O₅
• Molecular Weight: 446.627
• Mol file: 120312-51-8.mol

Synonyms:4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol

Chemical Property of 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol

There total 5 articles about 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-5-Bromo-1-(1-methoxy-1-methyl-ethoxy)-pent-2-ene → 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol (120312-51-8)

Guidance literature:

Multi-step reaction with 3 steps

3: 1.) Li, MgBr₂, Li₂CuCl₄; 2.) Pyr*HOTs / 1.) Et₂O, THF, HMPA; 2.) MeOH

With dilithium tetrachlorocuprate; pyridinium p-toluenesulfonate; lithium; magnesium bromide;

DOI:10.1021/ja00191a057

Reference yield:

(2R,3R)-2-(4-Benzyloxy-butyl)-3-bromomethyl-oxirane (120331-95-5) → 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol (120312-51-8)

Guidance literature:

Multi-step reaction with 3 steps

3: 1.) Li, MgBr₂, Li₂CuCl₄; 2.) Pyr*HOTs / 1.) Et₂O, THF, HMPA; 2.) MeOH

With dilithium tetrachlorocuprate; pyridinium p-toluenesulfonate; lithium; magnesium bromide;

DOI:10.1021/ja00191a057

Reference yield:

(Z)-7-(benzyloxy)hept-2-en-1-ol (99016-97-4) → 4-{(2S,3R)-3-[3-((2R,3S)-3-{3-[(2S,3R)-3-(4-Benzyloxy-butyl)-oxiranyl]-propyl}-oxiranyl)-propyl]-oxiranyl}-butan-1-ol (120312-51-8)

Guidance literature:

Multi-step reaction with 4 steps

4: 1.) Li, MgBr₂, Li₂CuCl₄; 2.) Pyr*HOTs / 1.) Et₂O, THF, HMPA; 2.) MeOH

With dilithium tetrachlorocuprate; pyridinium p-toluenesulfonate; lithium; magnesium bromide;

DOI:10.1021/ja00191a057

upstream raw materials:

1-Bromo-3-(1-methoxy-1-methyl-ethoxy)-propane

C₂₄H₃₅BrO₄

(Z)-7-(benzyloxy)hept-2-en-1-ol

(2R,3R)-2-(4-Benzyloxy-butyl)-3-bromomethyl-oxirane

Downstream raw materials:

(R)-5-Benzyloxy-1-(2S,6R,2'S,6'R,2''R)-dodecahydro-[2,2';6',2'']terpyran-6-yl-pentan-1-ol