(R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid

Base Information

• Chemical Name: (R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid
• CAS No.: 206068-51-1
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 206068-51-1.mol

Synonyms:(R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid

Chemical Property of (R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid

There total 2 articles about (R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R)-3-((R)-2,2-Dimethyl-1-nitromethyl-propyl)-4-phenyl-oxazolidin-2-one (189350-22-9) → (R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid (206068-51-1)

Guidance literature:

With acetic acid; sodium nitrite; In dimethyl sulfoxide; at 40 ℃; for 28h;

Reference yield:

(E)-3,3-dimethyl-1-nitrobut-1-ene (20429-42-9,165881-29-8) → (R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid (206068-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butoxide; 18-crown-6 / tetrahydrofuran / 1 h / 0 °C

1.2: 87 percent / tetrahydrofuran / 0.25 h / -78 °C

2.1: 89 percent / sodium nitrite; acetic acid / dimethylsulfoxide / 28 h / 40 °C

With 18-crown-6 ether; potassium tert-butylate; acetic acid; sodium nitrite; In tetrahydrofuran; dimethyl sulfoxide; 1.1: Metallation / 1.2: Addition / 2.1: Oxidation;

Reference yield: 88.0%

(R)-3,3-Dimethyl-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid (206068-51-1) → D-tert-leucine (26782-71-8)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 0.5h;

upstream raw materials:

(R)-3-((R)-2,2-Dimethyl-1-nitromethyl-propyl)-4-phenyl-oxazolidin-2-one

(E)-3,3-dimethyl-1-nitrobut-1-ene

Downstream raw materials:

D-tert-leucine