[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone

Base Information

• Chemical Name: [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone
• CAS No.: 119539-99-0
• Molecular Formula: C₂₈H₂₂N₂O₂
• Molecular Weight: 418.495

Synonyms:[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone

Chemical Property of [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone

Chemical Property:

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Technology Process of [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone

There total 5 articles about [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanol (119518-01-3) → [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone (119539-99-0)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 1h; sonication;

DOI:10.1002/jhet.5570270716

Reference yield:

2-bromonaphthalene (580-13-2) → [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone (119539-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 30 min, then r.t.

2: 99 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / sonication

With n-butyllithium; pyridinium chlorochromate; In dichloromethane;

DOI:10.1002/jhet.5570270716

Reference yield:

1-(4-Methoxyphenyl)-5-(4-methylphenyl)pyrazol-3-ylcarboxaldehyde (119518-09-1) → [1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanone (119539-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 30 min, then r.t.

2: 99 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / sonication

With n-butyllithium; pyridinium chlorochromate; In dichloromethane;

DOI:10.1002/jhet.5570270716

upstream raw materials:

[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-naphthalen-2-yl-methanol

2-bromonaphthalene

1-(4-Methoxyphenyl)-5-(4-methylphenyl)pyrazol-3-ylcarboxaldehyde

3-Hydroxymethyl-1-(4-methoxyphenyl)-5-(4-methylphenyl)pyrazole

Downstream raw materials:

(Z)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-naphthalen-2-yl-acrylic acid ethyl ester

(E)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-naphthalen-2-yl-acrylic acid ethyl ester

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