Technology Process of 6-chloro-3-[4-(ethylsulfonyl)phenyl]-2-quinolinamine
There total 6 articles about 6-chloro-3-[4-(ethylsulfonyl)phenyl]-2-quinolinamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium acetate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,2-dimethoxyethane; water;
at 80 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-Bromosuccinimide / acetic acid / 3.5 h / 70 - 115 °C
2: trifluoromethylsulfonic anhydride; urea hydrogen peroxide adduct / dichloromethane
3: trichlorophosphate / 1 h / Reflux
4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 40 h / 130 °C / Sealed tube
5: trifluoroacetic acid / 3 h / 65 °C
6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 2 h / 80 °C
With
N-Bromosuccinimide; trifluoromethylsulfonic anhydride; potassium acetate; urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,2-dimethoxyethane; dichloromethane; water; acetic acid; butan-1-ol;
6: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trifluoromethylsulfonic anhydride; urea hydrogen peroxide adduct / dichloromethane
2: trichlorophosphate / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / butan-1-ol / 40 h / 130 °C / Sealed tube
4: trifluoroacetic acid / 3 h / 65 °C
5: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 2 h / 80 °C
With
trifluoromethylsulfonic anhydride; potassium acetate; urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,2-dimethoxyethane; dichloromethane; water; butan-1-ol;
5: Suzuki Coupling;
