N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide

Base Information

• Chemical Name: N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide
• CAS No.: 866186-93-8
• Molecular Formula: C₂₇H₂₆N₄O₆S
• Molecular Weight: 534.593
• Mol file: 866186-93-8.mol

Synonyms:N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide

Chemical Property of N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide

There total 5 articles about N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(1H-indol-3-yl)-2-(2-nitro-benzenesulfonylamino)-propionic acid (140645-39-2) + (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (18881-17-9,62855-02-1,62928-94-3,63006-93-9) → N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide (866186-93-8)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.06.035

Reference yield:

methyl ((2-nitrophenyl)sulfonyl)-D-tryptophanate (866186-92-7) → N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide (866186-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / aq. LiOH / methanol

2: 77 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole; triethylamine / dimethylformamide

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.06.035

Reference yield:

L-Tic-OH (74163-81-8) → N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide (866186-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / BH₃*SMe₂; BF₃*OEt₂ / tetrahydrofuran

2: 77 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole; triethylamine / dimethylformamide

With dimethylsulfide borane complex; boron trifluoride diethyl etherate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.06.035

upstream raw materials:

3-(1H-indol-3-yl)-2-(2-nitro-benzenesulfonylamino)-propionic acid

(S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

methyl ((2-nitrophenyl)sulfonyl)-D-tryptophanate

L-Tic-OH