benzyl methyl aminomalonate hydrochloride

Base Information

• Chemical Name: benzyl methyl aminomalonate hydrochloride
• CAS No.: 127953-30-4
• Molecular Formula: C₁₁H₁₃NO₄*ClH
• Molecular Weight: 259.689
• Mol file: 127953-30-4.mol

Synonyms:benzyl methyl aminomalonate hydrochloride

Chemical Property of benzyl methyl aminomalonate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl methyl aminomalonate hydrochloride

There total 5 articles about benzyl methyl aminomalonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

2-[(Z)-Hydroxyimino]-malonic acid benzyl ester methyl ester (118283-56-0) → benzyl methyl aminomalonate hydrochloride (127953-30-4)

Guidance literature:

With water; acetic acid; aluminium; mercury dichloride; In diethyl ether; Ambient temperature;

DOI:10.1021/jm00111a002

Reference yield:

benzyl methyl malonate (52267-39-7) → benzyl methyl aminomalonate hydrochloride (127953-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95.4 percent / acetic acid, sodium nitrite / H₂O / Ambient temperature

2: 27 percent / glacial acetic acid, Al, mercuric chloride, H₂O / diethyl ether / Ambient temperature

With water; acetic acid; aluminium; mercury dichloride; sodium nitrite; In diethyl ether; water;

DOI:10.1021/jm00111a002

Reference yield:

Boc-Ama(OBn)-OMe (118317-76-3) → benzyl methyl aminomalonate hydrochloride (127953-30-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 12h; Yield given; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19981007)81:10<1845::AID-HLCA1845>3.0.CO;2-L

upstream raw materials:

2-[(Z)-Hydroxyimino]-malonic acid benzyl ester methyl ester

Boc-Ama(OBn)-OMe

tert-butoxycarbonylamino-acetic acid benzyl ester

Boc-Ama(OBn)-OH

Downstream raw materials:

2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-malonic acid benzyl ester methyl ester

Boc-Leu-Ama(OMe)-OBn

Boc-Ala-Leu-Ama(OMe)-OBn

Boc-Val-Ala-Leu-Ama(OMe)-OBn