14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

Base Information

Chemical Name:14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine
CAS No.:1429118-95-5
Molecular Formula:C₂₆H₂₅NO₄
Molecular Weight:415.489
Hs Code.:

Synonyms:14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

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Chemical Property of 14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

Chemical Property:

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Technology Process of 14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

There total 15 articles about 14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₆ClNO₄

: 1429118-95-5
14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 1429118-95-5
14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 14 h / Reflux

2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C

3: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere

4: formic acid; triethylamine; Noyori's catalyst / N,N-dimethyl-formamide / 20 °C

5: water; sodium hydroxide / ethanol / 3 h / 20 °C

6: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C

7: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C

With pyridine; Noyori's catalyst; formic acid; thionyl chloride; water; sodium hydrogencarbonate; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3: |Bischler-Napieralski Reaction;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 1429118-66-0
C₂₈H₂₉NO₆

: 1429118-95-5
14-(R)-10-benzyloxy-2,3-methylenedioxy-9-methoxytetrahyrdooxyprotoberberine

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol / 3 h / 20 °C

2: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C

3: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C

With thionyl chloride; water; sodium hydrogencarbonate; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.12.016