Technology Process of (-)-2,3,3aS,8aR-tetrahydro-4-hydroxy-6-methoxy[2,3-d]-benzo[b]furan
There total 1 articles about (-)-2,3,3aS,8aR-tetrahydro-4-hydroxy-6-methoxy[2,3-d]-benzo[b]furan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: (R)-α,α-diphenyl-2-pyrrolidinemethanol derived catalyst / acetonitrile / 5 h / 20 °C
2.1: AcOH / 48 h / 110 °C
2.2: 40 percent / aq. H2SO4 / 1 h / 75 °C
3.1: 80 percent / DMAP; pyridine / CH2Cl2 / 2 h / 0 °C
4.1: tetrahydrofuran; diethyl ether / 2 h / -20 °C
5.1: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C
6.1: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C
7.1: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C
With
pyridine; dmap; (R)-α,α-diphenyl-2-pyrrolidinemethanol derived catalyst; hydrogen; urea hydrogen peroxide adduct; nickel; Dess-Martin periodane; acetic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
5.1: Dess-Martin oxidation / 6.1: Baeyer-Villiger oxidation;
DOI:10.1021/ja054503m
- Guidance literature:
-
With
sodium hydrogencarbonate; zinc(II) carbonate;
In
dichloromethane;
at 20 ℃;
for 20h;
DOI:10.1021/ja054503m
