(E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

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Chemical Name:(E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid
CAS No.:868616-88-0
Molecular Formula:C₂₁H₁₇FN₂O₃
Molecular Weight:364.376
Hs Code.:

Synonyms:(E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

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Chemical Property of (E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

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Technology Process of (E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

There total 5 articles about (E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: ethyl 2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoate

: 868616-88-0
(E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

Guidance literature:: ethyl 2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoate; With potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; at 4 ℃; for 2h; pH=7; Inert atmosphere;
DOI:10.1021/jm501799k

Reference yield:

: 1-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)ethanone

: 868616-88-0
(E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: ammonium acetate; acetic acid / benzene / 20 h / Inert atmosphere; Reflux; Dean-Stark

3.1: potassium hydroxide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 4 °C / pH 7 / Inert atmosphere

With ammonium acetate; sodium ethanolate; acetic acid; potassium hydroxide; In tetrahydrofuran; benzene;
DOI:10.1021/jm501799k

Reference yield:

: ethyl 4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-2-hydroxy-4-oxobut-2-enoate

: 868616-88-0
(E/Z)-2-amino-4-(1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / benzene / 20 h / Inert atmosphere; Reflux; Dean-Stark

2.1: potassium hydroxide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 4 °C / pH 7 / Inert atmosphere

With ammonium acetate; acetic acid; potassium hydroxide; In tetrahydrofuran; benzene;
DOI:10.1021/jm501799k