(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

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Chemical Name:(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester
CAS No.:128684-66-2
Molecular Formula:C₅₄H₆₉N₇O₈
Molecular Weight:944.184
Hs Code.:

(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

Synonyms:(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

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Chemical Property of (R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

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Technology Process of (R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

There total 3 articles about (R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 128684-59-3
N-(carboxymethyl)-D-Leu-benzyl ester hydrochloride

: 128684-47-9
{(S)-5-((R)-2-Amino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentyl}-carbamic acid benzyl ester; hydrochloride

: 128684-66-2
(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00171a034

Reference yield:

: 17664-93-6
(R)-benzyl 2-amino-4-methylpentanoate p-toluenesulfonate salt

: 128684-66-2
(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / Et₃N / tetrahydrofuran / 144 h / Ambient temperature

2: 95 percent / 3N HCl / ethyl acetate

3: 93 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a034

Reference yield:

: (R)-2-(tert-Butoxycarbonylmethyl-amino)-4-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

: 128684-66-2
(R)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 3N HCl / ethyl acetate

2: 93 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a034