N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

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Chemical Name:N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide
CAS No.:1369853-13-3
Molecular Formula:C₂₂H₂₁F₃N₂O₂
Molecular Weight:402.416
Hs Code.:

Synonyms:N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

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Chemical Property of N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

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Technology Process of N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

There total 4 articles about N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1369852-61-8
N-[2-(1-benzyl-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

: 107-02-8,25068-14-8
acrolein

: 1369853-13-3
N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Guidance literature:: N-[2-(1-benzyl-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide; With n-butyllithium; In diethyl ether; at 0 - 20 ℃; for 2h; Inert atmosphere;

acrolein; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0031-1289656

Reference yield:

: 61-54-1
tryptamine

: 1369853-13-3
N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289656

Reference yield:

: 4307-98-6
N-benzyltryptamine

: 1369853-13-3
N-{2-[1-benzyl-2-(1-hydroxyallyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; In diethyl ether; dichloromethane;
DOI:10.1055/s-0031-1289656