3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

Base Information

Chemical Name:3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester
CAS No.:194991-98-5
Molecular Formula:C₄₂H₂₇F₅N₄O₉
Molecular Weight:826.69
Hs Code.:

3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

Synonyms:3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

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Chemical Property of 3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

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Technology Process of 3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

There total 5 articles about 3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 194991-96-3
N-2-(N^α-9-fluorenylmethoxycarbonylglycyl)aminoethyl-N'-(2-carboxyethyl)-1,4,5,8-naphthalenetetracarboxylic diimide

: 194991-98-5
3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 16h;
DOI:10.1021/ja9706108

Reference yield:

: 86060-85-7
Fmoc-Gly-OPfp

: 194991-98-5
3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HOBT, 2,6-lutidine / dimethylformamide / 4 h

2: 87 percent / DCC / dimethylformamide / 16 h

With 2,6-dimethylpyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/ja9706108

Reference yield:

: 3-[7-(2-tert-Butoxycarbonylamino-ethyl)-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl]-propionic acid benzyl ester

: 194991-98-5
3-(7-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-ethyl}-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-propionic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, 1,4-cyclohexadiene / Pd/C / ethanol / 48 h

2: TFA / CH₂Cl₂ / 0.17 h

3: HOBT, 2,6-lutidine / dimethylformamide / 4 h

4: 87 percent / DCC / dimethylformamide / 16 h

With 2,6-dimethylpyridine; cyclohexa-1,4-diene; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja9706108