N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide
CAS No.:1353875-45-2
Molecular Formula:C₃₀H₂₇F₂N₇O₃S
Molecular Weight:603.652
Hs Code.:

Synonyms:N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

Suppliers and Price of N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

There total 2 articles about N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259439-36-5
4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline

: 1353875-62-3
N-(3-(4-amino-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

: 1353875-45-2
N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In toluene; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1353875-61-2
5-bromo-2-morpholinopyrimidin-4-amine

: 1353875-45-2
N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / Inert atmosphere

1.2: 19 h / 90 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 18 h / 90 °C / Inert atmosphere

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In toluene;