N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine

Base Information

• Chemical Name: N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine
• CAS No.: 475467-17-5
• Molecular Formula: C₂₂H₁₆ClN₅O
• Molecular Weight: 401.855
• Mol file: 475467-17-5.mol

Synonyms:N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine

Chemical Property of N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine

There total 4 articles about N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

isoniazid (54-85-3,7640-37-1) + 1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde (36663-00-0) → N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine (475467-17-5)

Guidance literature:

With sulfuric acid; In ethanol; dichloromethane; Reflux;

DOI:10.1007/s00044-015-1340-x

Reference yield:

p-chloroacetophenone phenylhydrazone (57845-08-6) → N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine (475467-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1.5 h / 0 °C

1.2: 6 h / 0 - 20 °C / Reflux

2.1: acetic acid / ethanol / 4 h / Reflux

With acetic acid; trichlorophosphate; In ethanol;

DOI:10.1016/j.ejmech.2014.04.045

Reference yield:

para-chloroacetophenone (99-91-2) → N'-[3'-(4'''-chlorophenyl)-1'-phenyl-4'-pyrazolylmethylidene]-N-isonicotinoylhydrazine (475467-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / ethanol / 1 h / Reflux

2.1: trichlorophosphate / 1.5 h / 0 °C

2.2: 6 h / 0 - 20 °C / Reflux

3.1: acetic acid / ethanol / 4 h / Reflux

With acetic acid; trichlorophosphate; In ethanol;

DOI:10.1016/j.ejmech.2014.04.045

upstream raw materials:

isoniazid

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde

p-chloroacetophenone phenylhydrazone

para-chloroacetophenone

Downstream raw materials:

2-[3''-(4''''-chlorophenyl)-1''-phenylpyrazol-4''-yl]-5-(pyridin-4'-yl)-1,3,4-oxadiazole