(1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

Base Information

Chemical Name:(1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol
CAS No.:509150-91-8
Molecular Formula:C₃₅H₃₃NO₄
Molecular Weight:531.651
Hs Code.:

Synonyms:(1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

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Chemical Property of (1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

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Technology Process of (1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

There total 2 articles about (1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 112633-26-8
2,6-bis[(tosyloxy)methyl]pyridine

: 415920-00-2
(1R,2R)-1,2-diphenyl-2-(4-methoxybenzyloxy)ethanol

: 509150-91-8
(1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

Guidance literature:: (1R,2R)-1,2-diphenyl-2-(4-methoxybenzyloxy)ethanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;

2,6-bis[(tosyloxy)methyl]pyridine; In tetrahydrofuran; for 14h; Heating;

With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 ℃; for 12h; Further stages.;
DOI:10.1021/ja028698z

Reference yield:

: 52340-78-0
(R,R)-hydroxybenzoin

: 509150-91-8
(1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: TsOH*H₂O / toluene / 16 h / Heating

1.2: 99 percent / DIBAL / hexane; CH₂Cl₂ / 3 h / -78 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2.2: tetrahydrofuran / 14 h / Heating

2.3: 36 percent / DDQ; water / CH₂Cl₂ / 12 h / 0 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1021/ja028698z

Reference yield: 4.0%

: 509150-91-8
(1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol

: 112633-26-8
2,6-bis[(tosyloxy)methyl]pyridine

: (4R,5R,15R,16R)-4,5,15,16-Tetraphenyl-3,6,14,17-tetraoxa-23,24-diaza-tricyclo[17.3.1.1^8,12]tetracosa-1⁽²²⁾,8,10,12⁽²⁴⁾,19⁽²³⁾,20-hexaene

Guidance literature:: (1R,2R)-2-[6-((1R,2R)-2-Hydroxy-1,2-diphenyl-ethoxymethyl)-pyridin-2-ylmethoxy]-1,2-diphenyl-ethanol; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

2,6-bis[(tosyloxy)methyl]pyridine; In tetrahydrofuran; toluene; for 24h; Further stages.; Heating;
DOI:10.1021/ja028698z