methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine

Base Information

• Chemical Name: methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine
• CAS No.: 85035-98-9
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.371
• Mol file: 85035-98-9.mol

Synonyms:methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine

Chemical Property of methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine

There total 4 articles about methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methoxy-7, benzyl-2, dihydro-3,4 benzo (b) 5H-azepine (85035-93-4) → methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine (85035-98-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

DOI:10.1016/0040-4020(82)87018-X

Reference yield:

hydroxy-1, benzyl-1, methoxy-6 tetrahydro-1,2,3,4 naphtalene (18305-80-1) → methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine (85035-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HN₃, 2.) conc. H₂SO₄ / 1.) benzene, 0 deg C, 2.) 1 h

2: 75 percent / sodium borohydride / methanol / 0 °C

With sodium tetrahydroborate; tris-(2-chloro-ethyl)-amine; sulfuric acid; In methanol;

DOI:10.1016/0040-4020(82)87018-X

Reference yield:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → methoxy-7, benzyl-2, tetrahydro-2,3,4,5 benzo (b) 1H-azepine (85035-98-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) magnesium / 1.) ether, 2.) THF, 0 deg C, 1 h, then room temperature, 1 h

2: 1.) HN₃, 2.) conc. H₂SO₄ / 1.) benzene, 0 deg C, 2.) 1 h

3: 75 percent / sodium borohydride / methanol / 0 °C

With sodium tetrahydroborate; tris-(2-chloro-ethyl)-amine; sulfuric acid; magnesium; In methanol;

DOI:10.1016/0040-4020(82)87018-X

upstream raw materials:

methoxy-7, benzyl-2, dihydro-3,4 benzo (b) 5H-azepine

hydroxy-1, benzyl-1, methoxy-6 tetrahydro-1,2,3,4 naphtalene

azido-1, benzyl-1, methoxy-6 tetrahydro-1,2,3,4 naphtalene

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Refernces