4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

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Chemical Name:4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide
CAS No.:1369762-36-6
Molecular Formula:C₂₄H₂₈N₂O₄
Molecular Weight:408.497
Hs Code.:

Synonyms:4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

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Chemical Property of 4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

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Technology Process of 4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

There total 5 articles about 4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 591-17-3
meta-bromotoluene

: 1369762-29-7
4-(2,4-dimethoxybenzyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

: 1369762-36-6
4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In toluene; at 110 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1021/ol300468g

Reference yield:

: 1311822-87-3
tert-butyl 2-(2,4-dimethoxybenzylamino)-2-oxoethylcarbamate

: 1369762-36-6
4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

2: triethylamine / ethanol / 16 h / 100 °C / Molecular sieve

3: 3-chloro-benzenecarboperoxoic acid / 3 h / 0 °C

4: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 18 h / 110 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; palladium diacetate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1021/ol300468g

Reference yield:

: 35088-22-3
2-amino-N-(2,4-dimethoxybenzyl)acetamide

: 1369762-36-6
4-(2,4-dimethoxybenzyl)-3-oxo-2-m-tolyl-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 16 h / 100 °C / Molecular sieve

2: 3-chloro-benzenecarboperoxoic acid / 3 h / 0 °C

3: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 18 h / 110 °C / Sealed tube; Inert atmosphere

With palladium diacetate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In ethanol; toluene;
DOI:10.1021/ol300468g