(2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

Base Information

Chemical Name:(2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid
CAS No.:212010-22-5
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

Synonyms:(2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

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Technology Process of (2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

There total 2 articles about (2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 20972-37-6
(E)-4-(4-methoxyphenyl)-4-oxo-2-butenoic acid

: 212010-22-5
(2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

Guidance literature:: In methanol; at 45 ℃;
DOI:10.1016/j.tetasy.2005.04.024

Reference yield: 39.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 5711-41-1
3-(4-methoxybenzoyl)acrylic acid

: 212010-22-5
(2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

Guidance literature:: In ethanol; at 60 ℃; for 16h; diastereospecific reaction;
DOI:10.1002/ejoc.200701033

Reference yield:

: 212010-22-5
(2R)-4-(4-methoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

: (2R)-2-amino-4-hydroxy-4-(4-methoxyphenyl)butanoic acid

Guidance literature:: With hydrogen bromide; hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 4h; under 825.066 Torr;
DOI:10.1016/j.tetasy.2005.04.024