1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

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Chemical Name:1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea
CAS No.:1012877-47-2
Molecular Formula:C₂₃H₁₉ClFN₅O₂
Molecular Weight:451.888
Hs Code.:

Synonyms:1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

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Chemical Property of 1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

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Technology Process of 1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

There total 14 articles about 1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1012878-85-1
3-(5-amino-2-chloro-4-fluorophenyl)-1-methyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one

: 103-71-9
phenyl isocyanate

: 1012877-47-2
1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

Guidance literature:: With pyridine; In ethyl acetate; at 20 ℃; for 13h;

Reference yield: 84.0%

: 1012877-47-2
1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 1012877-47-2
1-(4-chloro-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1, 6-naphthyridin-3-yl)phenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 9 steps

1: 2 h / 120 °C

2: trichlorophosphate / 2 h / Reflux

3: water; acetonitrile / 8 h / 0 - 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5: manganese(IV) oxide / dichloromethane / 6 h / 30 °C

6: 40% potassium fluoride/alumina / N,N-dimethyl acetamide / 1 h / 20 °C

7: 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one / 3 h / 180 °C / Inert atmosphere

8: trifluoroacetic acid / dichloromethane / Reflux

9: pyridine / ethyl acetate / 13 h / 20 °C

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; 40% potassium fluoride/alumina; 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; acetonitrile;