(1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide

Base Information

• Chemical Name: (1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide
• CAS No.: 913962-65-9
• Molecular Formula: C₂₀H₃₃NO₂
• Molecular Weight: 319.488
• Mol file: 913962-65-9.mol

Synonyms:(1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide

Chemical Property of (1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide

There total 1 articles about (1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-hex-2-enamide (869468-00-8) + tert.-butyl lithium (594-19-4) → (1'S,2'S,3R)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide (913962-65-9) + (1'S,2'S,3S)-3-tert-butyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylhexanamide

Guidance literature:

With lithium chloride; In tetrahydrofuran; hexane; at -105 - 20 ℃;

DOI:10.1021/jo061205e

upstream raw materials:

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-hex-2-enamide

tert.-butyl lithium