methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate
CAS No.:1596367-49-5
Molecular Formula:C₂₄H₃₀O₅
Molecular Weight:398.499
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Suppliers and Price of methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

There total 30 articles about methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1154740-74-5
4,4,5,5-tetramethyl-2-(5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1,3,2-dioxaborolane

: 1596367-47-3
methyl 2-(3-benzyloxy-2-bromo-6-methylphenyl)-2-(tert-butoxy)-acetate

: 1596367-49-5
methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Guidance literature:: 4,4,5,5-tetramethyl-2-(5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1,3,2-dioxaborolane; methyl 2-(3-benzyloxy-2-bromo-6-methylphenyl)-2-(tert-butoxy)-acetate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 120 ℃;

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 3.5h; under 3750.38 Torr;

Reference yield:

: 1154740-74-5
4,4,5,5-tetramethyl-2-(5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1,3,2-dioxaborolane

: 1596367-47-3
methyl 2-(3-benzyloxy-2-bromo-6-methylphenyl)-2-(tert-butoxy)-acetate

: 1596367-48-4
methyl 2-[3-benzyloxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]]-2-(tert-butoxy)acetate

: 1596367-49-5
methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; In 1,4-dioxane; at 120 ℃;

Reference yield:

: 101623-40-9
1-chloro-4-methyl-2-(prop-2-en-1-yloxy)benzene

: 1596367-49-5
methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 0.33 h / 240 °C / Microwave irradiation

2.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: bromine; acetic acid / 0.25 h / 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 16 h / 95 °C

6.1: palladium 10% on activated carbon; ammonium formate / methanol / 1 h / Reflux

7.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C

7.2: 3.5 h / 20 °C / 3750.38 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; bromine; ammonium formate; potassium acetate; sodium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;