(R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

Base Information

Chemical Name:(R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester
CAS No.:226213-90-7
Molecular Formula:C₂₀H₂₉NO₆
Molecular Weight:379.453
Hs Code.:

Synonyms:(R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

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Chemical Property of (R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

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Technology Process of (R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

There total 3 articles about (R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (R)-3-(2-Methoxycarbonyl-ethylamino)-4-phenyl-butyric acid methyl ester

: 226213-90-7
(R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 30 ℃; for 5h;
DOI:10.1021/jo000447q

Reference yield:

: (R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-4-phenyl-butyric acid methyl ester

: 226213-90-7
(R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 10 h

2: methanol / 20 °C

3: 67 percent / NaHCO₃ / dioxane / 5 h / 30 °C

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; 1: Catalytic hydrogenation / 2: Michael addition / 3: Acylation;
DOI:10.1021/jo000447q

Reference yield:

: 190446-31-2
methyl (3R)-3-amino-4-phenylbutanoate

: 226213-90-7
(R)-3-[N-(tert-butyloxycarbonyl)-N-(2-carbomethoxyethyl)]amino-4-phenylbutyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 20 °C

2: 67 percent / NaHCO₃ / dioxane / 5 h / 30 °C

With sodium hydrogencarbonate; In 1,4-dioxane; methanol; 1: Michael addition / 2: Acylation;
DOI:10.1021/jo000447q