5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

Base Information

Chemical Name:5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil
CAS No.:1620879-93-7
Molecular Formula:C₃₃H₃₂FIN₂O₅Se
Molecular Weight:761.49
Hs Code.:

Synonyms:5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

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Technology Process of 5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

There total 17 articles about 5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

: 1620879-93-7
5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 0 ℃; for 2.5h; stereoselective reaction;
DOI:10.1016/j.ejmech.2014.06.031

Reference yield:

: 1620879-54-0
(-)-2,2'-anhydro-5-iodo-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-seleno-D-arabinofuranosyl]uracil

: 1620879-93-7
5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 1.5 h / 0 - 20 °C

2: dmap; pyridine / 15 h / 20 - 55 °C

3: pyridinium p-toluenesulfonate / dichloromethane / 20 h / 0 - 20 °C

4: sodium hydroxide / acetonitrile / 2 h / 20 °C

5: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 0 °C

With pyridine; dmap; diethylamino-sulfur trifluoride; pyridinium p-toluenesulfonate; triethylamine tris(hydrogen fluoride); triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2014.06.031

Reference yield:

: 1620879-60-8
(-)-2,2'-anhydro-5-iodo-1-(4-seleno-D-arabinofuranosyl)uracil

: 1620879-93-7
5-iodo-1-(3-O-tetrahydropyranyl-5-O-trityl-4-seleno-D-arabinofuranosyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; pyridine / 15 h / 20 - 55 °C

2: pyridinium p-toluenesulfonate / dichloromethane / 20 h / 0 - 20 °C

3: sodium hydroxide / acetonitrile / 2 h / 20 °C

4: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 0 °C

With pyridine; dmap; diethylamino-sulfur trifluoride; pyridinium p-toluenesulfonate; sodium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2014.06.031